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News On Wall Street > Market News > Top 5 Trending Stocks in the U.S. Market Last Week
Market NewsTrading & Investing

Top 5 Trending Stocks in the U.S. Market Last Week

Marina D
Last updated: September 27, 2025 7:04 pm
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Marina D
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11 Min Read
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The U.S. stock market is buzzing with several high-profile movers. Based on Yahoo Finance trending data, here are five stocks making headlines today, with a mix of surging gainers and notable decliners. Each is trending due to significant news or unusual trading activity.

Contents
  • 1. Snow Lake Energy (LITM) – Critical Minerals Play on the Rise
  • 2. Datavault AI (DVLT) – Small Cap Skyrockets on Major Investment
  • 3. Plus Therapeutics (PSTV) – Biotech Soars on Insurance Coverage News
  • 4. Eli Lilly & Co. (LLY) – Pharma Giant Dips on Pipeline Setback
  • 5. Oracle Corp. (ORCL) – Big Tech Lags after Analyst Downgrade

1. Snow Lake Energy (LITM) – Critical Minerals Play on the Rise

Snow Lake Energy (NASDAQ: LITM), a Canadian mineral exploration company doing business as Snow Lake Energy, has captured investor interest with its strategic moves in the critical minerals space. The company recently diversified into uranium, antimony, and rare earth projects, which has put it on the trending tickers list.

  • Critical Minerals Investments: Snow Lake announced strategic stakes in multiple U.S. critical mineral projects, including a uranium project in Wyoming, an antimony project in Idaho, and a rare earth project in Quebec. These investments expand Snow Lake’s portfolio into high-demand minerals for clean energy and defense.
  • Stock Performance: After a 1-for-13 reverse stock split in May to maintain Nasdaq listing requirements, Snow Lake’s share price has been volatile. It recently closed around $4.20, with significant intraday swings – on the last trading day the stock fluctuated over 11% and ended down about 5%. Despite short-term dips, the stock is still up roughly 3% over the past two weeks.
  • Why It’s Trending: Investors are watching Snow Lake as a speculative critical-minerals play. The new project stakes position the company in the EV battery and clean energy supply chain, and any progress on its uranium and lithium initiatives could be game-changing. This mix of strategic news and notable price volatility has made LITM one of today’s trending U.S. stocks.

Big uranium news!

Snow Lake Energy ( $LITM ) just reported excellent drill results at its Pine Ridge Uranium Project in Wyoming.

With strong grades and drilling ongoing, traders are watching closely.

Would you load $LITM on your watchlist?$UUUU $CCJ $URNM $OKLO $NNE pic.twitter.com/bp6lyDrnil

— News On Wall Street (@NewsOnWallSt) September 26, 2025

2. Datavault AI (DVLT) – Small Cap Skyrockets on Major Investment

Datavault AI (NASDAQ: DVLT) has stormed onto the trending list after an eye-popping move. This tiny data-analytics and AI company more than doubled in value following a transformative funding announcement.

  • $150 Million Investment: DVLT secured a $150 million strategic investment from Scilex Holding Company, news that sent its shares soaring over 100%. This capital injection (notably executed in Bitcoin) provides resources for Datavault to scale its supercomputing and data exchange platform.
  • Surging Stock Price: The stock jumped from the ~$0.40 range to over $0.80, closing up 28% in one day and extending gains as the news sank in. Traders have embraced DVLT’s spike – a huge move for a penny stock – on extremely heavy volume.
  • Why It’s Trending: A triple-digit percentage gain will land any stock on the trending ticker list. In Datavault’s case, the combination of a big funding deal and buzz around its AI/data monetization patents (72 patents per company filings) has ignited retail trading interest. It’s a classic high-risk, high-reward microcap story driving watercooler chatter today.

$dvlt 🚀🚀🚀 this will be official Samsung partnership in a few weeks waiting official confirmation hence the big institutional investments so big money can buy before us so lock in early 🚀💎 pic.twitter.com/xSfzlAXYju

— Crypzhroom 🪄🍄🫧 (@Sdaviesvilla) September 25, 2025

3. Plus Therapeutics (PSTV) – Biotech Soars on Insurance Coverage News

Plus Therapeutics (NASDAQ: PSTV) is another big gainer grabbing attention. This clinical-stage biotech jumped after announcing a milestone in commercializing its cancer diagnostics.

  • UnitedHealthcare Deal: Plus Therapeutics secured a national coverage agreement with UnitedHealthcare for its CNSide™ cerebrospinal fluid test for metastatic cancer. This deal extends insurance coverage of the test to over 51 million people across the U.S. – a huge commercial win for the company.
  • Share Price Jump: PSTV stock surged nearly 40% on the news, finishing around $0.56 per share. Traders cheered the validation by a major insurer, which should help drive adoption of the company’s diagnostic. The volume spiked as investors speculated this coverage could accelerate revenue growth.
  • Why It’s Trending: It’s not every day a penny-stock biotech lands a deal with a top insurance provider. The prospect of broader patient access to Plus Therapeutics’ test (with 92% sensitivity and 95% specificity per clinical data) has injected optimism. The stock’s sharp rally and increased message board chatter have made PSTV one of today’s hottest small-cap stories.

$PSTV The company's unique positioning in radiotherapy particularly in the development of orphan drugs for rare cancers could bring significant market potential Market attention has increased recently

The target price is $7.88, suggesting a potential upside of up to 1761.56%🚀 pic.twitter.com/Ju4GoVTFeh

— Donald L Cole (@carmen_rz_) September 25, 2025

4. Eli Lilly & Co. (LLY) – Pharma Giant Dips on Pipeline Setback

Not all trending stocks are winners today – pharma heavyweight Eli Lilly (NYSE: LLY) is trending after an abrupt drop. Lilly’s stock fell following news of a disappointment in its drug pipeline, putting it on many traders’ radar.

  • Trial Halted: Lilly announced it ended a Phase 2 trial of an experimental obesity drug only weeks after it began, a setback in its high-profile obesity/diabetes pipeline. The drug, acquired via a $2 billion buyout in 2023, showed promise for weight loss but raised safety concerns, prompting Lilly to halt the trial early.
  • Stock Slides: In reaction, Lilly shares sank ~3.7% to around $714. This drop, on higher-than-normal volume, made LLY one of the top trending tickers. Notably, the decline came despite Lilly also announcing an FDA approval of a new breast cancer drug the same day – positive news that was overshadowed by the obesity drug setback.
  • Why It’s Trending: Lilly has been a market darling due to its booming diabetes and weight-loss franchises, so any crack in that story draws attention. The surprise trial termination shocked some investors, triggering a sell-off and lively discussion about its implications. With Lilly still up dramatically year-to-date, dip-buyers and skeptics alike are watching closely – landing LLY on the trending list as a big-name stock in the news.

$LLY … Eli Lilly rose 1.7% following President Donald Trump's announcement late Thursday that pharmaceutical companies would face a 100% tariff on branded or patented drugs unless they are currently building plants in the U.S. Lilly is one of many big pharma companies that… pic.twitter.com/piA6QQlRPd

— Marty Chargin (@MartyChargin) September 26, 2025

5. Oracle Corp. (ORCL) – Big Tech Lags after Analyst Downgrade

Rounding out the list is Oracle (NYSE: ORCL), which is trending for less upbeat reasons. The enterprise software giant’s stock is under pressure after Wall Street cast some doubt on its lofty valuation.

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  • “Sell” Rating Hits Stock: Oracle shares fell about 5% after an analyst initiated coverage with an unusual “Sell” rating, citing concerns over the company’s near-term growth outloo. This bearish call caught investors’ attention since Oracle had been on a strong run in 2025, up over 80% for the year before this pullback.
  • Market Reaction: The stock dropped from roughly $308 to $291, erasing billions in market cap. Oracle’s decline made it one of the day’s top trending tickers as traders debated whether this dip is a buying opportunity or a sign of further weakness. The company’s recent earnings beat was overshadowed by worries about its cloud growth deceleration and rich stock price.
  • Why It’s Trending: It’s not often you see a mega-cap like Oracle downgraded to “Sell,” so the news made waves. With high trading volume and media buzz about Oracle’s valuation, the stock’s slide has become a watercooler topic. This mix of analyst-driven news and significant price move firmly placed ORCL among today’s most followed U.S. stocks.

$ORCL + TikTok happening 🤯 pic.twitter.com/ajtmRb6vzZ

— Eva Ados (@eva_ados) September 25, 2025

Each of these five stocks – from tiny Snow Lake Energy to blue-chip Oracle – is trending because something out of the ordinary is happening. Whether it’s explosive gains on good news or sharp drops on setbacks, traders are intently watching these names. Always remember, trending status can be fleeting, so it’s wise to research the fundamentals behind the buzz (and the sources cited) before jumping in.


Lusso’s News, LLC (“we,” “our,” or “the Company”) has been compensated fifteen thousand U.S. dollars (USD $15,000) by a third party for investor awareness and media coverage related to Snow Lake Resources Ltd. (NASDAQ: LITM). This compensation is for a six-month period beginning June 2025 and ending December 2025. The content provided by Lusso’s News, LLC, including but not limited to articles, videos, social media posts, and other media, is intended for informational and educational purposes only and does not constitute investment advice or a recommendation to buy or sell any securities. We are not registered as a broker-dealer, investment advisor, or in any other capacity with the U.S. Securities and Exchange Commission (SEC) or any state securities authority. This material may contain forward-looking statements, including projections, forecasts, estimates, and other information that is predictive in nature. Forward-looking statements are subject to a number of risks and uncertainties, many of which are beyond the control of Snow Lake Resources Ltd. or Lusso’s News, LLC, that could cause actual results to differ materially from those anticipated. Readers should not place undue reliance on such statements. Investing in securities, particularly micro-cap and small-cap stocks, involves substantial risk, including the potential for total loss of principal. Always conduct your own independent research and consult with a licensed financial advisor before making any investment decisions. Lusso’s News, LLC assumes no responsibility or liability for any investment decisions made based on the information we provide. By viewing our content, you acknowledge and agree to these terms.

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